New publication in Dalton Trans. online
A new generation of terminal copper nitrenes and their application in aromatic C–H amination reactions
Nitrenes are a highly reactive nitrogen species with six valence electrons. These can be stabilized by copper(I) bis(pyrazolyl)methane complexes at low temperatures and be applied for the direct C–H amination and the aziridination of styrene derivatives.
In this publication, three novel copper nitrene complexes with different third N donor moieties were synthesized. They were characterized with different methods, for example UV/Vis spectroscopy and ultra-high resolution cryo ESI mass spectrometry. Furthermore, the structure of the copper nitrene complexes was studied by DFT and DLPNO(T) calculations. The copper nitrene complexes were applied for the C–H amination of challenging substrates like benzene or cyclohexane. In addition, the aziridination of styrene derivatives was achieved in good yields. Moreover, the mechanism of the aziridination of Styrene was investigated experimentally and by DFT calculation.
The article A new generation of terminal copper nitrenes and their application in aromatic C–H amination reactions is available on the webpage of the publisher.